Blar i NTNU Open på forfatter "Ashcroft, Felicity"
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The Copenhagen Actinic Keratosis Study (COAKS). A decentralised clinical trial to evaluate tolerability, safety and efficacy of daily field-directed topical treatment with cytosolic phospholipase A<inf>2</inf> inhibitor, AVX001, in participants with actinic keratosis: protocol for a randomised controlled phase I/IIa trial
Ortner, Vinzent Kevin; Johansen, Berit; Kilov, Kim; Castillo Mondragón, Alejandro; Duvold, Tore; Kihl, Jesper; Ashcroft, Felicity; Feuerherm, Astrid Jullumstrø; Pind Laugesen, Charlotte; Marcker Espersen, Maiken Lise; Manole, Ionela; Isberg, Ari Pall; Andersen, Anders Daniel; Rakvaag, Elin; Zibert, John R.; Haedersdal, Merete (Peer reviewed; Journal article, 2022)ntroduction Actinic keratosis (AK) is the most common precancerous skin condition caused by long-term UV exposure. Given the high recurrence rate of 15%–53%, identifying safe and effective treatment options is warranted. ... -
cPLA2α Enzyme Inhibition Attenuates Inflammation and Keratinocyte Proliferation
Ashcroft, Felicity; Mahammad, Nur; Flatekvål, Helene Midtun; Feuerherm, Astrid Jullumstrø; Johansen, Berit (Journal article, 2020)As a regulator of cellular inflammation and proliferation, cytosolic phospholipase A2 α (cPLA2α) is a promising therapeutic target for psoriasis; indeed, the cPLA2α inhibitor AVX001 has shown efficacy against plaque psoriasis ... -
Inhibition of Cytosolic Phospholipase A2α Induces Apoptosis in Multiple Myeloma Cells
Mahammad, Nur; Ashcroft, Felicity; Feuerherm, Astrid Jullumstrø; Elsaadi, Samah; Vandsemb, Esten Nymoen; Børset, Magne; Johansen, Berit (Peer reviewed; Journal article, 2021)Cytosolic phospholipase A2α (cPLA2α) is the rate-limiting enzyme in releasing arachidonic acid and biosynthesis of its derivative eicosanoids. Thus, the catalytic activity of cPLA2α plays an important role in cellular ... -
Investigating the role of cPLA2α in macrophage polarization
Sridhar, Arun (Master thesis, 2021)Macrophages are involved in the pathogenesis of many inflammatory diseases including fibrosis, asthma, and atherosclerosis. These macrophages possess remarkable plasticity which allows them to respond to diverse ... -
Investigation into the effects of inhibiting cytosolic phospholipase A2 alpha on the proliferation of an immortalized keratinocyte cell line (HaCaT).
Flatekvål, Helene Midtun (Master thesis, 2020)Psoriasis er en vanlig kronisk inflammatorisk sykdom som er karakterisert ved hyperproliferering og unormal differensiering av epidemis. Det er ingen kur, og det har vært lite forbedring i utviklingen av nye behandlinger ... -
Investigation of the inflammatory response in human monocytes and macrophages exposed to micro- and nanoplastics in vitro
Altermark, Sofie (Master thesis, 2023)Mennesker eksponeres for mikro- og nanoplast (MNP) i økende mengder gjennom inntak av mat og drikke, innånding og hudkontakt. Likevel er innvirkningen disse partiklene kan ha på menneskers helse fortsatt ikke fullt ut ... -
Logical and experimental modeling of cytokine and eicosanoid signaling in psoriatic keratinocytes
Tsirvouli, Eirini; Ashcroft, Felicity; Johansen, Berit; Kuiper, Martin (Peer reviewed; Journal article, 2021)Psoriasis is a chronic skin disease, in which immune cells and keratinocytes keep each other in a state of inflammation. It is believed that phospholipase A2 (PLA2)-dependent eicosanoid release plays a key role in this. ... -
Logical Modeling of Basal Cell Carcinoma Keratinocytes for Drug Target Prediction
Aker, Ingrid (Master thesis, 2022)Keratinocyttkarsinom, nemlig basalcellekreft og plateepitelkreft, er kreft som oppstår på huden hovedsakelig grunnet overdreven soleksponering. Disse hudkreftformene metastaserer sjeldent, men til tross for dette kan de ... -
The role of bioactive lipids in keratinocyte hyperproliferation
Lunden, Hanne Enakshi (Master thesis, 2023)Hyperprolifering i keratinocytter er et kjennetegn i sykdomsutviklingen i flere hudsykdommer, som psoriasis, aktin keratose, og keratinocyttkarsinom. Mekanismene som driver keratinocytt hyperproliferering kan bli knyttet ...